Covid-19, Gender And Immune Response: What’s The Relationship?

Current knowledge of immunity suggests that strong innate immune responses likely contribute to the lower disease severity and mortality outcomes associated with females. Elevated levels of toll-like receptor 7 and IFNα, along with decreased levels of interleukin 6, may correlate to better prognoses in women. On the other hand, the worse clinical outcomes observed in men could be explained by their higher levels of ACE2 and epigenetic changes in their immune cells, These mechanisms leave important clues to understanding the relationship between biological sex and immune responses to SARS-CoV-2 infection, but these associations are not linear.

Source: Covid-19, Gender And Immune Response: What’s The Relationship?

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