They found three compounds that could prevent the reversal of fmo-2 induction in the presence of food: an antidepressant that blocks the neurotransmitter serotonin, and two antipsychotic drugs used to treat schizophrenia, both of which block the neurotransmitter dopamine.
“We know serotonin and dopamine are major players in the reward portion of the brain and tend to be involved in satiety and food response signals,” said Leiser. “The fact that the drugs we found were antagonizing this suggests you are blocking aspects of these pathways.” Ultimately, the drugs enabled the life extension effect of FMO, even in the presence of the smell of food.
These specific drugs are unlikely to be prescribed for this effect however, given their many potentially dangerous side effects. But they provide important clues about the fmo-2 activation pathway and its effect on life extension.
Source: Serotonin and Dopamine Modulate Aging in Response to Food Odor and Availability – Neuroscience News