Summary: A smaller version of the amyloid-beta protein, AB 1-40, builds up on the wall of small arteries and reduces blood flow to the brain, a new study reports.
Source: University of Manchester
A breakthrough in our understanding of Alzheimer’s disease has revealed changes to blood vessels in the brain, potentially presenting a path for developing new drugs to help fight the disease, according to University of Manchester research published today in Proceedings of the National Academy of Sciences (PNAS).
Alzheimer’s Disease is traditionally thought of as a disease of the brain cells, where a protein called Amyloid-beta (Aβ) accumulates and forms plaques. There is growing evidence that the blood supply to the brain is also affected, however, how this happens is unknown.